BMC Biology Table of Contents - May 2018
Read how advances in microscopy allow imaging of large samples and living organisms, and more
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This month's content from BMC Biology comprises a diverse mix of research papers and commissioned content articles, including what Drosophila tells us about environmental triggers of innate immunity, how early life diets affect responses to poor diet in later life, and the landscapes of differentiating regulatory T cells.

Also found below are the latest additions to our thematic series. New to In the Light of Evolution are research from Eörs Szathmáry describing how the 'Fifth Rule' (a biological version of the Fifth Commandment) can spread by natural selection; and an Opinion piece by Eric Bapteste and Philippe Huneman arguing that thinking in terms of a Network, rather than Tree, of life can help evolutionary theory better explain the evolution of biological complexity and diversity. Raju Tomer and colleagues present Light Sheet Theta Microscopy as a high-speed and high-resolution method to image large samples - part of New Tools for Neurobiology.

These series, along with Protein Quality Control at Membranes, are continuing to welcome submission of research articles: please submit here.

In response to the recent outbreaks of Ebola in DR Congo, we would also like to announce that our editors will treat submissions relevant to Ebola research with priority.

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Featured articles

Rapid High-Resolution Imaging of Large Biological Samples

Light Sheet Theta Microscopy, developed by Raju Tomer and colleagues allows rapid, high-resolution imaging of large samples, such as human brain slices, expanded tissues, or highly motile animals like Hydra.


Identification and removal of small RNA contaminants

In new research, Paul Wilmes and colleagues report that RNA isolation and purification can leave behind small RNA contaminants, which can also be identified in published datasets.


Tiny wasps, biological pest control, and evolution of miniaturization

Amelia Lindsey and colleagues report the genome of the miniature parasitoid wasp Trichogramma pretiosum, providing insights into its biology and applications as pest control.


Crystal clear enzyme catalysis

A commentary from Allen Orville dicusses dynamic structural biology, in the light of recent research in BMC Biology demonstrating the general applicability of time-resolved crystallography.

Featured collection - Opinions

Junk DNA, aging and DNA methylation, ebola, HIV, mathematical modelling and more. This collection presents commissioned Opinion articles to provide coverage of current or emerging topics, as well as a discussion of possibly controversial views, different models and theories in the field.

Table of contents

Review and Comment

Entering an era of dynamic structural biology...

Allen M. Orville


Towards a Dynamic Interaction Network of Life to unify and expand the evolutionary theory

Eric Bapteste and Philippe Huneman




Dehydration triggers ecdysone-mediated recognition-protein priming and elevated anti-bacterial immune responses in Drosophila Malpighian tubule renal cells

Wenjing Zheng, Florentina Rus, Ana Hernandez, Ping Kang, William Goldman, Neal Silverman and Marc Tatar


Enzyme intermediates captured "on the fly" by mix-and-inject serial crystallography

Jose L. Olmos Jr, Suraj Pandey, Jose M. Martin-Garcia, George Calvey, Andrea Katz, Juraj Knoska, Christopher Kupitz, Mark S. Hunter, Mengning Liang, Dominik Oberthuer, Oleksandr Yefanov, Max Wiedorn, Michael Heyman, Mark Holl, Kanupriya Pande, Anton Barty...


Comparative genomics of the miniature wasp and pest control agent Trichogramma pretiosum

Amelia R. I. Lindsey, Yogeshwar D. Kelkar, Xin Wu, Dan Sun, Ellen O. Martinson, Zhichao Yan, Paul F. Rugman-Jones, Daniel S. T. Hughes, Shwetha C. Murali, Jiaxin Qu, Shannon Dugan, Sandra L. Lee, Hsu Chao, Huyen Dinh, Yi Han, Harsha Vardhan Doddapaneni...


Light sheet theta microscopy for rapid high-resolution imaging of large biological samples
Bianca Migliori, Malika S. Datta, Christophe Dupre, Mehmet C. Apak, Shoh Asano, Ruixuan Gao, Edward S. Boyden, Ola Hermanson, Rafael Yuste and Raju Tomer


Caring for parents: an evolutionary rationale

J. Garay, S. Számadó, Z. Varga and E. Szathmáry


Small RNA profiling of low biomass samples: identification and removal of contaminants

Anna Heintz-Buschart, Dilmurat Yusuf, Anne Kaysen, Alton Etheridge, Joëlle  V. Fritz, Patrick May, Carine de Beaufort, Bimal B. Upadhyaya, Anubrata Ghosal, David J. Galas and Paul Wilmes


Time-resolved transcriptome and proteome landscape of human regulatory T cell (Treg) differentiation reveals novel regulators of FOXP3

Angelika Schmidt, Francesco Marabita, Narsis A. Kiani, Catharina C. Gross, Henrik J. Johansson, Szabolcs Éliás, Sini Rautio, Matilda Eriksson, Sunjay Jude Fernandes, Gilad Silderberg, Ubaid Ullah, Urvashi Bhatia, Harri Lähdesmäki, Janne Lehtiö, David Gomez-Cabrero, Heinz Wiendl...


Early life diet conditions the molecular response to post-weaning protein restriction in the mouse

Amy F. Danson, Sarah J. Marzi, Robert Lowe, Michelle L. Holland and Vardhman K. Rakyan

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The BMC Biology Editorial Team

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