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Genome Biology is pleased to share with you our July content update, featuring journal news, top articles and our most recent table of contents.

Journal news

We welcome back Chief Editor Barbara Cheifet after her maternity leave.

Genome Biology
 and its sister journals BMC Biology and Genome Medicine now provide the opportunity for co-submissions, where authors submit a manuscript for joint consideration at two of these journals at the same time. Co-submissions provide a faster publication process, saving authors' time and avoiding the need for multiple submissions. You can learn more about co-submissions here.
Featured articles

 et al 
Klein et al
Functional characterization of enhancer evolution in the primate lineage

Klein et al. monitor and identify evolutionary-functional trajectories of primate liver enhancers. 84 allelic variants associated with enhancer functionality were identified to be enriched for cytosine deamination within CpGs. This is a promising source of evolutionary novelty.
Yokoyama et al

Epistasis analysis uncovers hidden antibiotic resistance-associated fitness costs hampering the evolution of MRSA

Yokoyama et al. highlight the mupirocin-resistance conferring mutation of the gene encoding the IleRS enzyme has pleiotropic effects on the S. aureus proteome.

Prins et al
Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6

Using large-scale population-based exome-chip analysis, Prins et al. identify an association between ventricular depolarization and rare non-synonymous variants in ADAMTS6. These are proposed to have a novel role in regulating gap junction-mediated ventricular depolarization of the heart.
Table of contents





From squiggle to basepair: computational approaches for improving nanopore sequencing read accuracy

Rang, Kloosterman and de Ridder


Timing somatic events in the evolution of cancer

Jolly and Van Loo


Splicing heterogeneity: separating signal from noise

Wan and Larson


Making genome browsers portable and personal

Khan and Zhang


The healthy ageing gene expression signature for Alzheimer's disease diagnosis: a random sampling perspective

Jacob and Speed




A large-scale whole-genome sequencing analysis reveals highly specific genome editing by both Cas9 and Cpf1 (Cas12a) nucleases in rice

Tang et al.  


Horizontal transfer of BovB and L1 retrotransposons in eukaryotes

Ivancevic et al.


Alternative DNA secondary structure formation affects RNA polymerase II promoter-proximal pausing in humans
Szlachta et al.

DNMT3A and TET1 cooperate to regulate promoter epigenetic landscapes in mouse embryonic stem cells

Gu et al.


Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6

Prins et al


Epistasis analysis uncovers hidden antibiotic resistance-associated fitness costs hampering the evolution of MRSA

Yokoyama et al


Differential gene expression analysis tools exhibit substandard performance for long non-coding RNA-sequencing data

Assefa et al


Wnt evolution and function shuffling in liberal and conservative chordate genomes

Somorjai et al.


Functional characterization of enhancer evolution in the primate lineage

Klein et al


DNA Topoisomerase I differentially modulates R-loops across the human genome

Manzo et al


Chromatin loop anchors are associated with genome instability in cancer and recombination hotspots in germline

Kaiser and Semple


The genomic impact of historical hybridization with massive mitochondrial DNA introgression

Seixas, Melo-Ferreira and Boursot


Selection-driven cost-efficiency optimization of transcripts modulates gene evolutionary rate in bacteria

Seward and Kelly




GIVE: portable genome browsers for personal websites

Cao et al.  

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