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Dear Colleague,

 

 

Genome Biology is pleased to share with you our August content update, featuring journal news, top articles and our most recent table of contents.

 
 
 
Journal news

 
 
Associate Editor Kevin Pang will be attending the Human Microbiome Meeting in Heidelberg from September 16-19th. Email us to set up a meeting.

Genome Biology
 and its sister journals BMC Biology and Genome Medicine now provide the opportunity for co-submissions, where authors submit a manuscript for joint consideration at two of these journals at the same time. Co-submissions provide a faster publication process, saving authors' time and avoiding the need for multiple submissions. You can learn more about co-submissions here.
 
 
 
Featured articles

 
 et al 
Agami et al
Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescence

Han et al. use CRISPR technology to identify a novel signalling cascade involving the interaction of AP1 with novel enhancer EnhAP1-OIS1, and activation of FOXF1 that regulates oncogene-induced senescence.
 
 
 
Odom et al

CTCF maintains regulatory homeostasis of cancer pathways

Aitken et al. conduct genomic and epigenetic profiling on Ctcfhemizygous mice in order to understand maintenance of genome function and integrity. Aitken and colleagues found changes in gene expression from reduction in CTCF in the transcriptomes of mouse and human tumors.

 
 
 
 
Featured collection

 
 
International Wheat Genome Sequencing

International Wheat Genome Sequencing Consortium 

The International Wheat Genome Sequencing Consortium (IWGSC) has sequenced and published a high quality genome sequence of bread wheat; the world's most widely cultivated crop. The article regarding the reference sequence and three other main articles were published in the international journal ScienceGenome Biology published four companion papers alongside Science. The article by Alaux et al. contains all sequence data now accessible to the public.

 
 
 
 
Table of contents
 

  

 

Comment

REVIEW

Single-cell RNAseq for the study of isoforms - how is that possible?

Arzalluz-Luque and Conesa

RESEARCH HIGHLIGHT

Investigating enhancer evolution with massively parallel reporter assays

Kwon and Ernst

RESEARCH HIGHLIGHT

Adding resolution and dimensionality to comparative genomics: moving from reference genomes to clade genomics

Rogers

COMMENT

Consumer genomics will change your life, whether you get tested or not

Khan and Mittelman

CORRECTION

Correction to: Genome-wide discovery and characterization of maize long non-coding RNAs

Li et al. 

 

Research

RESEARCH

CTCF maintains regulatory homeostasis of cancer pathways

Aitken et al.

RESEARCH

Homeobox oncogene activation by pan-cancer DNA hypermethylation

Su et al.

RESEARCH

Evolutionarily conserved partial gene duplication in the Tritceae tribe of grasses confers pathogen resistance

Rajaraman et al.

RESEARCH

Cell type-specific CLIP reveals that NOVA regulates cytoskeleton interactions in motoneurons

Yuan et al. 

RESEARCH

Optical and physical mapping with local finishing enables megabase-scale resolution of agronomically important regions in the wheat genome

Keeble-Gagnère et al. 

RESEARCH

Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescence

Han et al

RESEARCH

Chromosome-scale compartive sequence analysis unravels molecular mechanisms of genome dynamics between two wheat cultivars

Thind et al

RESEARCH

A simple genetic basis of adaptation to a novel thermal environment results in complex metabolic rewiring in Drosophila

Mallard et al.

RESEARCH

Comparative transcriptomic analyses and single-cell RNA sequencing of the freshwater planarian Schmidtea mediterranea identify major cell types and pathway conservation

Swapna et al. 

RESEARCH

Interaction between the microbiome and TP53 in human lung cancer

Greathouse et al. 

 
 
 

Method

METHOD

QsRNA-seq: a method for high throughput profiling and quantifying small RNAs

Fishman, Light and Lamm

METHOD

CRISPR-SKIP: programmable gene splicing with single base editors

Gapinske et al. 

METHOD

STRetch: detecting and discovering pathogenic short tandem repeat expansions

Dashnow et al. 

 
 
 

Software

SOFTWARE

HiGlass: web-based visual exploration and analysis of genome interaction maps

Kerpedjiev et al
 
 
 

Database

DATABASE

Linking the International Wheat Genome Sequencing Consortium bread wheat reference genome sequence to wheat genetic and phenomic data

Alaux et al. 

 
 
 
 
 
 
 
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