BMC Biology Table of Contents - December 2018
Pathological mutations in MYD88, a new cyclops from algae, a rhythm for each personality, and more
BMC Biology
About   How to Submit  
Editorial Board   Article Alerts
Dear Colleague,
  Happy 2019 from the BMC Biology team!

We'd like to start this year by letting you know about our new Transfers and Portable Peer Review Policy. Launched in an effort to reduce time spent on serial submissions and iterative reviewing, this policy supports sharing of reviews obtained at BMC Biology with any journal of the authors' choice, including those outside of BMC and Springer Nature. We are also able to consider manuscripts on the basis of reviews at other journals. Learn how we support a pragmatic and streamlined peer review with this policy from our recent Editorial

This month's Research articles includes the latest addition to our In the Light of Evolution series, on the heritability of collective-level - group property - traits; and work on how variations in circadian rhythmicity are associated with zebrafish personality types. Methodology articles tackling current challenges in genome engineering are presented: the introduction of multiallelic gene disruption, and a new fluorescent reporter to track and enrich base-edited cells.

You can still submit to our upcoming special issue on Cancer Metabolism - read more about the issue, and submit your manuscript, here. Our new cross-journal series with Genome Biology, Microbiome Biology is also now open for submissions.

Our January Focus features Reviews across the BMC Flagships on approaches to data analysis, including Meta-evaluation of meta-analysis: ten appraisal questions for biologists, and A practical guide to single-cell RNA-sequencing for biomedical research and clinical applications. Check the other Reviews included in the Focus by visiting our homepage.

If you have any questions, or if you would like to inquire about the potential suitability of a manuscript for publication in BMC Biology, don't hesitate to contact us at

Follow us on Twitter and Facebook
Featured articles
Tackling waste in publishing
Tackling waste in publishing through portable peer review

Our Editorial delineates how BMC Biology supports peer review through its new Transfers and Portable Peer Review policy.
Pathological mutations
Pathological mutations and self-assembly of MyD88

Yann Gambin and colleagues describe how pathological mutations in the immune signaling molecule Myd88 affect its prion-like polymerisation and lead to loss- and gain-of function responses.
Cyclops from Algae
A new Cyclops from Algae

Armin Hallmann, George Nagel and colleagues report a novel opsin family from green algae, showing that these light-inhibited guanylyl cyclases are regulated through a two-component-like phosphoryl transfer, naming them "two-component cyclase opsins" (2c-Cyclops).
Rhythm for each personality
A Rhythm for Each Personality

Christian Tudorache and colleagues ask whether variations in circadian rhythmicity are associated with zebrafish personality types and show that proactive "first in their class" fish, and reactive "follower" fish have distinct rhythms of their physiological responses. 
Featured series - Environment and Sustainability
Environment and Sustainability

This collection brings together articles addressing questions in ecology, sustainability and the environmental challenges of the Anthropocene: from Research on plasticity of plant pathogen genomes, to Reviews covering endonuclease systems - like CRISPR-Cas9 - in pest control, and the unpredictability of emerging plant pathogens under climate change.

Table of contents

Review and Comment

Tackling waste in publishing through portable peer review

Graham P. Bell and Mirna Kvajo




BE-FLARE: a fluorescent reporter of base editing activity reveals editing characteristics of APOBEC3A and APOBEC3B
Matthew A. Coelho, Songyuan Li, Luna Simona Pane, Mike Firth, Giovanni Ciotta, Jonathan D. Wrigley, Maria Emanuela Cuomo, Marcello Maresca and Benjamin J. M Taylor


Homology-independent multiallelic disruption via CRISPR/Cas9-based knock-in yields distinct functional outcomes in human cells

Chenzi Zhang, Xiangjun He, Yvonne K. Kwok, Feng Wang, Junyi Xue, Hui Zhao, Kin Wah Suen, Chi Chiu Wang, Jianwei Ren, George G. Chen, Paul B. S. Lai, Jiangchao Li, Yin Xia, Andrew M. Chan, Wai-Yee Chan and Bo Feng


Pathological mutations differentially affect the self-assembly and polymerisation of the innate immune system signalling adaptor molecule Myd88

Ailís O’Carroll, Brieuc Chauvin, James W. P. Brown, Avan Meagher, Joanna Coyle, Jurgen Schill, Akshay Bhumkhar, Dominic J. B. Hunter, Thomas Ve, Bostjan Kobe, Emma Sierecki and Yann Gambin


Biological clock function is linked to proactive and reactive personality types

Christian Tudorache, Hans Slabbekoorn, Yurie Robbers, Eline Hin, Johanna H. Meijer, Herman P. Spaink and Marcel J. M. Schaaf


Mitochondrial unfolded protein response transcription factor ATFS-1 promotes longevity in a long-lived mitochondrial mutant through activation of stress response pathways

Ziyun Wu, Megan M. Senchuk, Dylan J. Dues, Benjamin K. Johnson, Jason F. Cooper, Leira Lew, Emily Machiela, Claire E. Schaar, Heather DeJonge, T. Keith Blackwell and Jeremy M. Van Raamsdonk

Trait heritability in major transitions

Matthew D. Herron, Seye A. Zamani-Dahaj and William C. Ratcliff


Two-component cyclase opsins of green algae are ATP-dependent and ligh-inhibited guanylyl cyclases

Yuehui Tian, Shiqiang Gao, Eva Laura von der Heyde, Armin Hallmann and Georg Nagel

Reasons to publish with us

Hospitable publishing process
. BMC Biology offers rapid evaluation and clear and continuous communication on the progress of your manuscript.


High visibility. All content is open access immediately on publication. Papers that are published in BMC Biology are featured on our website with article-level metrics and promoted via press releases, blogs and social media.

Flexible formatting. To facilitate the submission process, we are flexible with regard to the format, style and length of initial submissions.

Scoop protection. BMC Biology offers "scoop protection", meaning that if other researchers publish similar findings after submission, or post them on a preprint server, this will not be a reason for rejection.

Co-submissions to other BMC ‘flagship’ journals. If a paper is potentially appropriate in scope for BMC Biology and Genome Biology or Genome Medicine authors have the opportunity to submit a manuscript for joint consideration at two of these journals at the same time. Learn more here.


Innovative practices and policies. Our re-review opt out policy allows authors to choose whether reviewers see their revisions, minimizing the time to publication. The innovative Registered Reports article format supports transparency and minimizes research and publication bias.

bioRxiv transfers. BMC Biology is happy to consider manuscripts that have been, or will be, posted on a preprint server. Authors are able to submit their manuscripts directly from bioRxiv, without having to re-upload files.

Submit your manuscript

Best regards,

The BMC Biology Editorial Team

Follow us on:
BMC Biology on Twitter   BMC Biology on Facebook   BMC on YouTube   Linkedin Icon
This email was sent to $email$.

This is how to ensure we´re always delivering our latest content to your inbox.

You have received this message as a result of opting in to hear from the journals or subject areas you've specified, BMC events, webinars and community news. To modify your subscription (including adding or removing subjects), click here.

Use this unsubscribe link to stop receiving any further messages from BMC.

For further information or enquiries please use our Contact page details.

BMC respects your privacy and does not disclose, sell or rent your personal information to any nonaffiliated third parties without your consent. Privacy Policy.

BioMed Central Ltd.
The Campus, 4 Crinan Street,
London, N1 9XW, 
United Kingdom
SpringerNature logo
©2019 BioMed Central | Part of Springer Nature