BMC Biology Table of Contents - January 2019
Tolerating cuckoldry in the family, subcellular sequencing of mRNA isoforms, and more
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  This month's content from BMC Biology covers a broad spectrum of Research and Commissioned pieces, from tolerating cuckoldry in the family, to subcellular sequencing of mRNA isoforms.

Our research articles below include how the Y chromosome of the channel catfish provides insights into sex determination; a comprehensive look at how high temperature can be used for high genome editing efficiency with CRISPR-Cas12a; a new model of multi-drug resistance in Mycobacterium tuberculosis, and using base editing to create mouse models of hypercholesterolemia.

The first piece in our Engineering Biology series arrives this month: a Review on thawing out frozen metabolic accidents from Dario Leister. The series is open for submissions of research articles, see here for more information. Don't forget you can still submit to our upcoming special issues on Cancer Metabolism and Microbiome Biology too!

Our Focus collection of Reviews across the BMC Flagships is on Microbial Communities and Therapeutics. Don't miss a review on microbial multiomics, and three pieces on antibiotic resistance - how to map it, effects on the microbiome, and why - although bad - it isn't worse.

BMC Biology supports portable peer review by sharing reviews and evaluating papers based on existing reports. Interested in transferring your manuscript and reviews? Learn more from our new Transfers and Portable Peer Review Policy and Editorial.

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Featured articles
Building upon past mistakes
Building upon past mistakes

In his review, Dario Leister covers the conditions under which photosynthesis evolved, and how it might be improved upon - from our Engineering Biology series.
Examining hard-to-penetrate surfaces
Taking a detailed look at hard-to-penetrate surfaces

A new tool for imaging reflective opaque samples - in color and 3D - at mesoscale magnification; Sebastian Munck and colleagues present ALMOST.
Sub-cellular localization of neuronal RNA
Sub-cellular localization of neuronal RNA

Junhyong Kim and colleagues perform independent RNA-sequencing for the soma and dendrites of individual mouse neurons, revealing transcript localization.
How were the Americas populated?
How were the Americas populated?

Ornella Semino and colleagues trace American genetic history providing insights into the geographic distribution of its Eurasian and American branches in modern and ancient samples.
Featured series - In the Light of Evolution
In the Light of Evolution

Read Research, Reviews, Q&As and more on evolutionary insights applied across biology, with pieces on the microbiome in evolution, the evolution of aging, how much of our genome is "junk" DNA, and human influences on wild populations as we enter the Anthropocene.

From the blog - Cuckoldry in the family
Cuckoldry in the family

In this blog post, Aneesh Bose, Jonathan Henshaw & Kristina Sefc discuss their new paper on when male fish might tolerate extra suitors intruding on their territories and mating with their partners.

Table of contents

Review and Comment

Thawing out frozen metabolic accidents
Dario Leister




Inclusive fitness benefits mitigate costs of cuckoldry to socially paired males
Aneesh P. H. Bose, Jonathan M. Henshaw, Holger Zimmermann, Karoline Fritzsche and Kristina M. Sefc


Application of CRISPR-Cas12a temperature sensitivity for improved genome editing in rice, maize and Arabidopsis

Aimee A. Malzahn, Xu Tang, Keunsub Lee, Qiurong Ren, Simon Sretenovic, Yingxiao Zhang, Hongqiao Chen, Minjeong Kang, Yu Bao, Xuelian Zheng, Kejun Deng, Tao Zhang, Valeria Salcedo, Kan Wang, Yong Zhang and Yiping Qi


The Y chromosome sequence of the channel catfish suggests novel sex determination mechanisms in teleost fish

Lisui Bao et al. 


A deletion in the RD105 region confers resistance to multiple drugs in Mycobacterium tuberculosis

Lianhua Qin, Jie Wang, Junmei Lu, Hua Yang, Ruijuan Zheng, Zhonghua Liu, Xiaochen Huang, Yonghong Fen, Zhongyi Hu and Baoxue Ge


Comprehensive catalog of dendritically localized mRNA isoforms from sub-cellular sequencing of single mouse neurons
Sarah A. Middleton, James Eberwine and Junhyong Kim


Analysis of the human Y-chromosome haplogroup Q characterizes ancient population movements in Eurasia and the Americas

Viola Grugni et al.


In vivo genome and base editing of a human PCSK9 knock-in hypercholesterolemic mouse model
Alba Carreras et al


A Label-free Multicolor Optical Surface Tomography (ALMOST) imaging method for nontransparent 3D samples

Axelle Kerstens, Nikky Corthout, Benjamin Pavie, Zengjin Huang, Frank Vernaillen, Greetje Vande Velde and Sebastian Munck

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