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Dear Colleague,

 

 

Genome Biology is pleased to share with you our January content update, featuring journal news, top articles and our most recent table of contents.

 
 
Journal news

 
 

Chief Editor Barbara Cheifet will be attending and speaking at the Lorne Genome Conference from February 17-19th.

Senior Editor Yixin Yao will be attending the Keystone Genome Engineering: From Mechanisms to Therapies conference in Victoria, British Columbia from February 19th-23rd. Email us to set up a meeting.


Genome Biology
and its sister journals BMC Biology and Genome Medicine now provide the opportunity for co-submissions, where authors submit a manuscript for joint consideration at two of these journals at the same time. Co-submissions provide a faster publication process, saving authors’ time and avoiding the need for multiple submissions. You can learn more about co-submissions here.


From 1st January 2019, all research reviewed at Genome Biology will undergo transparent peer review. Please see our Editorial for more details.

 
 
Featured articles

 
 
 
Oh et al

Implications of circadian oscillations of cytosine on epigenetic variability, aging, and complex disease

Oh and colleagues highlight that circadian oscillations in cytosine modification can have an impact on aging and common diseases in later life.

 
 
 
Hansen et al

Comparison of human gut bacteria in populations of rural Africa and the US

Hansen et al compare the gut microbiota of rural populations in Tanzania and Botswana and individuals living in the US city of Philadelphia.

 
 
 
Zhu et al

Re-designed guide RNAs boost CRISPR-pooled screens

Zhu and colleagues improve genetic screens by using innovative modified guide RNAs with internal barcodes integrated into their structure.

 
 
 
 
Table of contents
 
 
 


Comment

EDITORIAL

Keen on the tenure track, are you? Know these things, you should
Voight

EDITORIAL

Where is genomics going next?

Cheifet

EDITORIAL

Evolutionary genomics: the fruits of genomic approaches applied to evolutionary biology
Sands

 
 
 

Research

SHORT REPORT
iGUIDE: an improved pipeline for analyzing CRISPR cleavage specificity

Bushman et al. 

SHORT REPORT

Degradation of endogenous proteins and generation of null-like phenotype in zebrafish using Trim-Away technology

Tang et al

RESEARCH

Recombination of ecologically and evolutionarily significant loci maintains genetic cohesion in the Pseudomonas syringae species complex

Guttman et al

RESEARCH

Circadian oscillations of cytosine modification in humans contribute to epigenetic variability, aging, and complex disease
Petronis et al

RESEARCH
GC-biased gene conversion conceals the prediction of the nearly neutral theory in avian genomes
Mugal et al

RESEARCH
Systematic evaluation of C. elegans lincRNAs with CRISPR knockout mutants

Shan et al. 

RESEARCH

Exosomal miR-196a derived from cancer-associated fibroblasts confers cisplatin resistance in head and neck cancer through targeting CDKN1B and ING5

Zhang et al. 

RESEARCH

Population structure of human gut bacteria in a diverse cohort from rural Tanzania and Botswana

Tishkoff et al

RESEARCH

Multiple-gene targeting and mismatch tolerance can confound analysis of genome-wide pooled CRISPR screens

Martin et al

RESEARCH

Genomic introgression through interspecific hybridization counteracts genetic bottleneck during soybean domestication

Wang, Chen and Ma

CORRECTION

Correction to: RNA G-quadruplexes at upstream open reading frames cause DHX36- and DHX9-dependent translation of human mRNAs

Balasubramanian et al. 

CORRECTION

Correction to: Applications and potential of genome editing in crop improvement

Goa et al

 
 

 

Method

METHOD

An amplicon-based sequencing framework for accurately measuring intrahost virus diversity using PrimalSeq and iVar

Andersen et al.  


METHOD

Accurate prediction cell type-specific transcription factor binding

Keilwagen, Posch and Grau

METHOD

Prediction of functional microRNA targets by integrative modeling of microRNA binding and target expression data

Liu and Wang

METHOD

Guide RNAs with embedded barcodes boost CRISPR-pooled screens

Wei et al

 
 
 

Database

DATABASE

The Network of Cancer Genes (NCG): a comprehensive catalogue of known and candidate cancer genes from cancer sequencing screens

Ciccarelli et al.

 
 
 

Software


SOFTWARE

plyranges: a grammar of genomic data transformation

Lee, Cook and Lawrence

 
 
 
 
 
 
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