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Genome Biology is pleased to share with you our July content update, featuring journal news, top articles and our most recent table of contents.

Journal news

Microbiome Biology Special Issue launched

The special issue on Microbiome Biology, guest edited by Rob Knight (UC San Diego, USA), Ruth Ley (MPI for Developmental Biology, Tuebingen, Germany), Elizabeth Grice (University of Pennsylvania, USA) and Jeroen Raes (KU Leuven, Belgium), has launched. The special issue, joint with BMC Biology, will be publishing research, methods, and reviews covering diverse areas of microbiome research. Look for our content being published over the next several months here.

Meet the Editors

Senior Editor Yixin Yao will be attending the Epigenetic and Chromatin Biology Congress from August 15-18th in Beijing. Email us to set up a meeting.

Featured articles

Qui et al

Modulating chromatin accessibility by transactivation and targeting proximal dsgRNAs enhances Cas9 editing efficiency in vivo

Qiu et alshow that Cas9 genome editing efficiency correlates with accessibility of chromatin in rice and generate a fusion construct to improve editing efficiency in open and closed chromatin regions.

Jiang et al

Frequent intra-and inter-species introgression shapes the landscape of genetic variation in bread wheat

Jiang et al. resequence 93 accessions of worldwide populations of bread wheat to reveal the significance of distant wild populations and alien species to its genetic composition and evolution. 

Schizophrenia risk

Cell type-specific epigenetic links to schizophrenia risk in the brain

Methylome and transcriptome data from patients with schizophrenia highlights the significance of cell type-specific epigenetic dysregulation in the disease.

Table of contents


Emerging technologies towards enhancing privacy in genomic data sharing

Bonnie Berger and Hyunghoon Cho

Population dynamics of the human gut microbiome: change is the only constant

Sambhawa Priya and Ran Blekhman


Challenges in funding and developing genomic software: roots and remedies
Adam Siepel


CDetection: CRISPR-Cas12b-based DNA detection with sub-attomolar sensitivity and single-base specificity

Fei Teng et al.

Integrative analysis of vascular endothelial cell genomic features identifies AIDA as a coronary artery disease candidate gene

Simon Lalonde et al.

Cell type-specific epigenetic links to schizophrenia risk in the brain

Isabel Mendizabal et al.

Frequent intra- and inter-species introgression shapes the landscape of genetic variation in bread wheat

Hong Cheng et al.

The bread wheat epigenomic map reveals distinct chromatin architectural and evolutionary features of functional genetic elements

Zijuan Li et al.

Stable enhancers are active in development, and fragile enhancers are associated with evolutionary adaptation
Shan Li et al.

Multilayered control of exon acquisition permits the emergence of novel forms of regulatory control

Nesli Avgan et al.

Benchmarking of alignment-free sequence comparison methods

Andrzej Zielezinski et al.

Spatial chromatin architecture alteration by structural variations in human genomes at the population scale

Michal Sadowski et al.

SMURF-seq: efficient copy number profiling on long-read sequencers
Rishvanth K. Prabakar et al.

GEMINI: a variational Bayesian approach to identify genetic interactions from combinatorial CRISPR screens

Mahdi Zamanighomi et al.

CONFINED: distinguishing biological from technical sources of variation by leveraging multiple methylation datasets

Mike Thompson et al. 

CellSIUS provides sensitive and specific detection of rare cell populations from complex single-cell RNA-seq data
Rebekka Wegmann et al.

RaPID: ultra-fast, powerful, and accurate detection of segments identical by descent (IBD) in biobank-scale cohorts

Ardalan Naseri et al.

Modulating chromatin accessibility by transactivation and targeting proximal dsgRNAs enhances Cas9 editing efficiency in vivo

Guanwen Liu et al.

HUPAN: a pan-genome analysis pipeline for human genomes

Zhongqu Duan et al.

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