BMC Biology Table of Contents – March 2020
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Dear Colleague,

BMC Biology is pleased to share with you our March content update, featuring journal news, selected article highlights, current open series, and our most recent table of contents.

We’re delighted to announce the launch of a new series, Research Synthesis and Meta-research in Biology. The series is now open and welcoming submissions of Research, Methodology and Software articles: for more information, visit the series homepage and read the inaugural editorial here. Papers in our Registered Reports format are welcomed and encouraged.

Don’t miss the latest review from our Engineering Biology collection, in which Mo Khalil and colleagues discuss protein aggregation, and how to harness properties of self-assembling systems  for synthetic biology.

Our research papers this month cover the spectrum of biology, from the evolution of metabolism and the mitochondrial proteome, to novel cancer therapeutics and sensitization to chemotherapy. You’ll also find work on whole-brain imaging, cellular responses to stress, and CRISPR gene drive systems in ecological engineering.

BMC Biology has a number of other thematic series that are open and welcoming submissions of research articles, including In the Light of Evolution, Cancer Metabolism, Environment and Sustainability, New Tools for Neurobiology, and Engineering Biology. See the full list here – and visit each series’ page for details of how to submit.

Our archived eTOC’s are available on our Goings On page, along with news and announcements from BMC Biology.


BMC Biology supports portable peer review by sharing reviews and evaluating papers based on existing reports. Interested in submitting? Learn more from our Transfers and Portable Peer Review Policy and Editorial.

If you have any questions, or if you would like to inquire about the potential suitability of a manuscript for publication in BMC Biology, don’t hesitate to contact us at

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Flagship focus

Each month the BMC flagships showcase a Focus collection – this month on Pathogens. Follow these links for the featured articles from Genome BiologyGenome MedicineBMC Biology and BMC Medicine.

Featured series

Research Synthesis and Meta-research in Biology

Our new series launches with an introduction from Guest Editors Shinichi Nakagawa, Julia Koricheva, Malcolm Macleod and Wolfgang Viechtbauer, and a call for submission of relevant papers.
Featured articles

Pervasive contamination in bacterial WGS datasets

New research from Galo Goig and colleagues finds that short-read contaminants are pervasive in bacterial whole-genome sequencing datasets, and that they can introduce large biases in variant analyses.

Full text | Download PDF
Chromosomal diversity in Aedes aegypti

Seth Redmond and colleagues characterize chromosomal diversity in subspecies of Aedes aegypti, creating a library of genomic rearrangements as an important resource for genetic studies of this mosquito vector.

Full text | Download PDF

The metabolic key to life transitions

Sider Penkov, Teymuras Kurzchalia and colleagues show that metabolic changes associated with growth to quiescence transition in C. elegans are directed by the concerted activity of regulatory pathways and changes in enzyme ratios.

Full text | Download PDF

Cautionary implications for combining immunotherapies

Mimicking the anti-CTLA4 therapy that is used to treat cancer patients in a mouse model,  Feng Wang and colleagues find altered T cell trafficking to gut tissues in the context of CTLA4-blockade, and a harmful rather than helpful outcome of applying of anti-integrin immunotherapy against colitis.

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Table of contents

Commissioned Content

Introducing our series: research synthesis and meta-research in biology

Shinichi Nakagawa et al.

BMC Biology 2020 18:20

Protein assembly systems in natural and synthetic biology

Giulio Chiesa et al.

BMC Biology 2020 18:35

Research Articles


Bivalent promoter hypermethylation in cancer is linked to the H327me3/H3K4me3 ratio in embryonic stem cells
Donnchadh S. Dunican et al.
BMC Biology 2020 18:25

DDX39B interacts with the pattern recognition receptor pathway to inhibit NF-κB and sensitize to alkylating chemotherapy
Szymon J. Szymura et al.
BMC Biology 2020 18:32


TDP-43 promotes the formation of neuromuscular synapses through the regulation of Disc-large expression in Drosophila skeletal muscles
Nina Strah et al.
BMC Biology 2020 18:34

A metabolic switch regulates the transition between growth and diapause in C. elegans

Sider Penkov et al.
BMC Biology 2020 18:31


Contaminant DNA in bacterial sequencing experiments is a major source of false genetic variability
Galo A. Goig et al.
BMC Biology 2020 18:24


The draft nuclear genome sequence and predicted mitochondrial proteome of Andalucia godoyi, a protist with the most gene-rich and bacteria-like mitochondrial genome
Michael W. Gray et al.
BMC Biology 2020 18:22

Evolution of metabolic capabilities and molecular features of diplonemids, kinetoplastids, and euglenids
Anzhelika Butenko et al.
BMC Biology 2020 18:23

Linked-read sequencing identifies abundant microinversions and introgression in the arboviral vector Aedes aegypti
Seth N. Redmond et al.
BMC Biology 2020 18:26


Identification of berberine as a novel drug for the treatment of multiple myeloma via targeting UHRF1
Chunming Gu et al.
BMC Biology 2020 18:33

The role of T cell trafficking in CTLA-4 blockade-induced gut immunopathology
Shashuang Zhang et al.
BMC Biology 2020 18:29


Performance analysis of novel toxin-antidote CRISPR gene drive systems
Jackson Champer et al.
BMC Biology 2020 18:27

Neuron ID dataset facilitates neuronal annotation for whole-brain activity imaging of C. elegans
Yu Toyoshima et al.
BMC Biology 2020 18:30


Persistent DNA damage triggers activation of the integrated stress response to promote cell survival under nutrient restriction
Elena Clementi et al.
BMC Biology 2020 18:36

A heat-sensitive Osh protein controls PI4P polarity
Deike J. Omnus et al.
BMC Biology 2020 18:28

Reasons to publish with us

Hospitable publishing process
. BMC Biology offers rapid evaluation and clear and continuous communication on the progress of your manuscript.


High visibility. All content is open access immediately on publication. Papers that are published in BMC Biology are featured on our website with article-level metrics and promoted via press releases, blogs and social media.

Flexible formatting. To facilitate the submission process, we are flexible with regard to the format, style and length of initial submissions.

Scoop protectionBMC Biology offers "scoop protection", meaning that if other researchers publish similar findings after submission, or post them on a preprint server, this will not be a reason for rejection.

Portable peer review. We support authors who wish to transfer a paper reviewed at BMC Biology to a journal of their choice. We are also able to consider manuscripts on the basis of reviews rejected at other journals, including those outside of BMC and Springer Nature. Find out more at our peer review policy page.

Co-submissions to other BMC ‘flagship’ journals. If a paper is potentially appropriate in scope for BMC Biology and Genome Biology or Genome Medicine authors have the opportunity to submit a manuscript for joint consideration at two of these journals at the same time. Learn more here.


Innovative practices and policies. Our re-review opt out policy allows authors to choose whether reviewers see their revisions, minimizing the time to publication. The innovative Registered Reports article format supports transparency and minimizes research and publication bias.

bioRxiv transfers. BMC Biology is happy to consider manuscripts that have been, or will be, posted on a preprint server. Authors are able to submit their manuscripts directly from bioRxiv, without having to re-upload files.

Submit your manuscript

Best regards,

The BMC Biology Editorial Team

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