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We are pleased to share with you our April content update, featuring journal news, top articles and our most recent table of contents.

 
Journal news

 
 

The special issue on Cancer Evolution and Metastasis, guest edited by Christina Curtis and Florian Markowetz has launched. The deadline for submissions has been extended to May 31st 2020. Please see the landing page for more details.

 
Featured articles

 
 
Successful generation of epigenetic disease model

Successful generation of epigenetic disease model mice by targeted demethylation of the epigenome


Hatada and colleagues show that successful generation of mice with targeted DNA demethylation at certain loci are useful for exploring epimutations in epigenetic diseases.


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Inference of single-cell phylogenies from lineage tracing data using Cassiopeia

Inference of single-cell phylogenies from lineage tracing data using Cassiopeia


Weissman et al develop Cassiopeia, a method for inference of single-cell phylogenies, and generate the largest lineage tracing dataset to date.


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A multidimensional systems biology analysis of cellular senescence in aging and disease

A multidimensional systems biology analysis of cellular senescence in aging and disease


Avelar and colleagues introduce a comprehensive cellular senescence database, CellAge, which reveals new roles of senescence in aging and disease.


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Table of contents
 

  

 

Comment

EDITORIAL

Open data in a deeply connected world

Barbara Cheifet

EDITORIAL

In memory of James Taylor: the birth of Galaxy

Anton Nekrutenko and Michael C. Schatz

 

Review

REVIEW

Lamina-associated domains: peripheral matters and internal affairs

Nolwenn Briand and Philippe Collas

 

REVIEW

Reverse-genetics studies of lncRNAs—what we have learnt and paths forward

Fan Gao et al.

 

Research

RESEARCH

Successful generation of epigenetic disease model mice by targeted demethylation of the epigenome

Takuro Horii et al.

 

RESEARCH

Leveraging biological and statistical covariates improves the detection power in epigenome-wide association testing

Jinyan Huang et al.

 

RESEARCH

The preceding root system drives the composition and function of the rhizosphere microbiome

Yi Zhao et al.

 

RESEARCH

Principles of RNA processing from analysis of enhanced CLIP maps for 150 RNA binding proteins

Eric L. Van Nostrand et al.

 

RESEARCH

A multidimensional systems biology analysis of cellular senescence in aging and disease

Roberto A. Avelar et al.

 

RESEARCH

Influenza infection elicits an expansion of gut population of endogenous Bifidobacterium animalis which protects mice against infection

Qiang Zhang et al.

 

RESEARCH

Wheat chromatin architecture is organized in genome territories and transcription factories

Lorenzo Concia et al.

 

METHOD

TADsplimer reveals splits and mergers of topologically associating domains for epigenetic regulation of transcription

Guangyu Wang et al.

 

METHOD

Inference of single-cell phylogenies from lineage tracing data using Cassiopeia

Matthew G Jones et al.

 

METHOD

Hi-D: nanoscale mapping of nuclear dynamics in single living cells

Haitham A. Shaban et al.

 

METHOD

Varlociraptor: enhancing sensitivity and controlling false discovery rate in somatic indel discovery

Johannes Köster et al.

 

METHOD

ExpansionHunter Denovo: a computational method for locating known and novel repeat expansions in short-read sequencing data

Egor Dolzhenko et al.

 

SOFTWARE

scATAC-pro: a comprehensive workbench for single-cell chromatin accessibility sequencing data

Wenbao Yu et al.

 

SOFTWARE

CCMetagen: comprehensive and accurate identification of eukaryotes and prokaryotes in metagenomic data

Vanessa R. Marcelino et al.

 

DATABASE

REPIC: a database for exploring the N6-methyladenosine methylome

Shun Liu et al.

 

DATABASE

CircAtlas: an integrated resource of one million highly accurate circular RNAs from 1070 vertebrate transcriptomes

Wanying Wu et al.

 
 
 
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